Burkholderia pseudomallei K96243, BPSS1502 (tssH-5)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse View in GBrowse

Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
Locus Tag
BPSS1502
Name
tssH-5
Synonym: clpV-5
Replicon chromosome 2
Genomic location 2046791 - 2049829 (+ strand)
CommentGene is part of a cluster known as the type VI secretion system gene cluster tss-5 used in much of the early P. pseudomallei literature (PMID:17660433) but later referred to as T6SS-1 cluster later (PMID:21670170, PMID:22007185) and by the B. mallei literature (PMID:22892068, PMID:17555434).

Cross-References

RefSeq YP_111509.1
GI 53722524
Entrez 3096694
GI 53722524
INSDC CAH38975.1
NCBI Locus Tag BPSS1502
RefSeq YP_111509.1,GeneID
UniParc UPI000043BD01
UniProtKB Acc Q63K63
UniProtKB ID Q63K63_BURPS
UniRef100 UniRef100_Q63K63
UniRef50 UniRef50_Q2T6Y8
UniRef90 UniRef90_I1WU89

Product

Feature Type CDS
Coding Frame 1
Product Name
type VI secretion system protein TssH-5
Product Name Confidence: Class 1
Synonyms Clp-type ATPase chaperone protein
TssH-5
Evidence for Translation
Charge (pH 7) -12.22
Kyte-Doolittle Hydrophobicity Value -0.140
Molecular Weight (kDa) 106781.9
Isoelectric Point (pI) 5.83

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

Virulence Evidence

Source 1
Database VFDB : VF0429
Category T6SS-1
Evidence ECO:0000314
direct assay evidence used in manual assertion
Host Organism
Notes
Reference 17984080

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 597 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG019354 (314 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSS1502
Search term: tssH-5

Human Homologs

Ensembl 86, assembly GRCh38.p7
ClpB homolog, mitochondrial AAA ATPase chaperonin [Source:HGNC Symbol;Acc:HGNC:30664]
E-value: 2.1e-39
Percent Identity: 36.5

References

In vivo expression technology identifies a type VI secretion system locus in Burkholderia pseudomallei that is induced upon invasion of macrophages.
Shalom G, Shaw JG, Thomas MS.
Microbiology. 2007 Aug;153(Pt 8):2689-99.
PubMed ID: 17660433
PubMed ID: 22007185
Type VI secretion is a major virulence determinant in Burkholderia mallei.
Schell MA(1), Ulrich RL, Ribot WJ, Brueggemann EE, Hines HB, Chen D, Lipscomb L, Kim HS, Mrázek J, Nierman WC, Deshazer D.
Mol Microbiol. 2007 Jun;64(6):1466-85.
PubMed ID: 17555434