Strain |
Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest |
Locus Tag |
BPSS1495
|
Name |
virA
Synonym: regA |
Replicon | chromosome 2 |
Genomic location | 2038711 - 2040555 (- strand) |
Comment | Gene is part of a cluster known as the type VI secretion system gene cluster tss-5 used in much of the early P. pseudomallei literature (PMID:17660433) but later referred to as T6SS-1 cluster later (PMID:21670170, PMID:22007185) and by the B. mallei literature (PMID:22892068, PMID:17555434). |
RefSeq | YP_111502.1 |
GI | 53722517 |
Entrez | 3096752 |
GI | 53722517 |
INSDC | CAH38968.1 |
NCBI Locus Tag | BPSS1495 |
RefSeq | YP_111502.1,GeneID |
UniParc | UPI000043BCFA |
UniProtKB Acc | Q63K70 |
UniProtKB ID | Q63K70_BURPS |
UniRef100 | UniRef100_Q63K70 |
UniRef50 | UniRef50_Q63K70 |
UniRef90 | UniRef90_Q63K70 |
Feature Type | CDS |
Coding Frame | 1 |
Product Name |
two-component regulatory system, sensor kinase VirA
|
Synonyms |
two-component regulator sensor kinase |
Evidence for Translation | |
Charge (pH 7) | 8.14 |
Kyte-Doolittle Hydrophobicity Value | 0.309 |
Molecular Weight (kDa) | 64369.0 |
Isoelectric Point (pI) | 8.59 |
Individual Mappings | |
Additional evidence for subcellular localization |
Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 528 genera
|
Burkholderia Ortholog Group |
BG001187 (1112 members) |
Putative Inparalogs | None Found |
STRING database | Search for predicted protein-protein interactions using:
Search term: BPSS1495
Search term: virA
Search term: two-component regulatory system, sensor kinase VirA
|
In vivo expression technology identifies a type VI secretion system locus in Burkholderia pseudomallei that is induced upon invasion of macrophages.
Shalom G, Shaw JG, Thomas MS
Microbiology 2007 Aug;153(Pt 8):2689-2699
PubMed ID: 17660433
|
The cluster 1 type VI secretion system is a major virulence determinant in Burkholderia pseudomallei.
Burtnick MN, Brett PJ, Harding SV, Ngugi SA, Ribot WJ, Chantratita N, Scorpio A, Milne TS, Dean RE, Fritz DL, Peacock SJ, Prior JL, Atkins TP, Deshazer D
Infect Immun 2011 Apr;79(4):1512-25
PubMed ID: 21300775
|
Strategies for Intracellular Survival of Burkholderia pseudomallei.
Allwood EM, Devenish RJ, Prescott M, Adler B, Boyce JD
Front Microbiol 2011;2:170
PubMed ID: 22007185
|
Type VI secretion is a major virulence determinant in Burkholderia mallei.
Schell MA, Ulrich RL, Ribot WJ, Brueggemann EE, Hines HB, Chen D, Lipscomb L, Kim HS, Mrázek J, Nierman WC, Deshazer D
Mol Microbiol 2007 Jun;64(6):1466-85
PubMed ID: 17555434
|
Regulation of type VI secretion system during Burkholderia pseudomallei infection.
Chen Y, Wong J, Sun GW, Liu Y, Tan GY, Gan YH
Infect Immun 2011 Aug;79(8):3064-73
PubMed ID: 21670170
|
Host Cytosolic Glutathione Sensing by a Membrane Histidine Kinase Activates the Type VI Secretion System in an Intracellular Bacterium.
Wong J, Chen Y, Gan YH
Cell Host Microbe 2015 Jul 8;18(1):38-48
PubMed ID: 26094804
|
Bacterial Reductionism: Host Thiols Enhance Virulence.
Sperandio V
Cell Host Microbe 2015 Jul 8;18(1):7-8
PubMed ID: 26159714
|