Burkholderia pseudomallei K96243, BPSS1390 (bpscC)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSS1390
Name
bpscC
Synonym: sctC
Replicon chromosome 2
Genomic location 1903732 - 1905498 (- strand)
CommentThis gene is part of the type III secretion system T3SS-1 locus found in B. pseudomallei but not B. mallei or B. thailandensis. B. pseudomallei T3SS-1 and T3SS-2, but not T3SS-3 contribute to pathogenicity in Solanum lycopersicum (tomato) but not human monocytic cell line THP-1. (PMID:20109238).

Cross-References

RefSeq YP_111402.1
GI 53722417
Entrez 3095732
GI 53722417
INSDC CAH38865.1
NCBI Locus Tag BPSS1390
RefSeq YP_111402.1,GeneID
UniParc UPI000043BC9F
UniProtKB Acc Q63KH0
UniProtKB ID Q63KH0_BURPS
UniRef100 UniRef100_A0A095RMN9
UniRef50 UniRef50_Q93L02
UniRef90 UniRef90_Q93L02

Product

Feature Type CDS
Coding Frame 1
Product Name
type III secretion system outer membrane ring protein / secretin BpscC (T3SS-1)
Product Name Confidence: Class 2
Synonyms type III secretion system protein
Evidence for Translation
Charge (pH 7) -2.88
Kyte-Doolittle Hydrophobicity Value -0.032
Molecular Weight (kDa) 62643.5
Isoelectric Point (pI) 6.44

Subcellular localization

Individual Mappings
Localization Confidence PMID
Outer Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 285 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG020866 (286 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSS1390
Search term: bpscC

Human Homologs

References

Identification of tomato plant as a novel host model for Burkholderia pseudomallei.
Lee YH, Chen Y, Ouyang X, Gan YH
BMC Microbiol 2010 Jan 29;10:28
PubMed ID: 20109238
Type III Secretion in the Melioidosis Pathogen <i>Burkholderia pseudomallei</i>.
Vander Broek CW, Stevens JM
Front Cell Infect Microbiol 2017;7:255
PubMed ID: 28664152
Role for the Burkholderia pseudomallei type three secretion system cluster 1 bpscN gene in virulence.
D'Cruze T, Gong L, Treerat P, Ramm G, Boyce JD, Prescott M, Adler B, Devenish RJ
Infect Immun 2011 Sep;79(9):3659-64
PubMed ID: 21768285
Evidence for the presence in Burkholderia pseudomallei of a type III secretion system-associated gene cluster.
Winstanley C, Hales BA, Hart CA
J Med Microbiol 1999 Jul;48(7):649-656
PubMed ID: 10403415
Distribution of type III secretion gene clusters in Burkholderia pseudomallei, B. thailandensis and B. mallei.
Rainbow L, Hart CA, Winstanley C
J Med Microbiol 2002 May;51(5):374-384
PubMed ID: 11990489
Type III secretion system cluster 3 is required for maximal virulence of Burkholderia pseudomallei in a hamster infection model.
Warawa J, Woods DE
FEMS Microbiol Lett 2005 Jan 1;242(1):101-8
PubMed ID: 15621426