Burkholderia pseudomallei K96243, BPSS0963 (bcaB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSS0963
Name
bcaB
Replicon chromosome 2
Genomic location 1273540 - 1274226 (+ strand)

Cross-References

RefSeq YP_110971.1
GI 53721986
Entrez 3095428
GI 53721986
INSDC CAH38425.1
NCBI Locus Tag BPSS0963
RefSeq YP_110971.1,GeneID
UniParc UPI000043BAFB
UniProtKB Acc Q63LQ0
UniProtKB ID Q63LQ0_BURPS
UniRef100 UniRef100_Q63LQ0
UniRef50 UniRef50_A1UV41
UniRef90 UniRef90_A1UV41

Product

Feature Type CDS
Coding Frame 1
Product Name
BcaB
Product Name Confidence: Class 1
Synonyms hypothetical protein
Evidence for Translation
Charge (pH 7) 5.48
Kyte-Doolittle Hydrophobicity Value -0.405
Molecular Weight (kDa) 25311.4
Isoelectric Point (pI) 8.50

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 7 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG019701 (319 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSS0963
Search term: bcaB
Search term: BcaB

Human Homologs

References

Systematic mutagenesis of genes encoding predicted autotransported proteins of Burkholderia pseudomallei identifies factors mediating virulence in mice, net intracellular replication and a novel protein conferring serum resistance.
Lazar Adler NR, Stevens MP, Dean RE, Saint RJ, Pankhania D, Prior JL, Atkins TP, Kessler B, Nithichanon A, Lertmemongkolchai G, Galyov EE
PLoS One 2015;10(4):e0121271
PubMed ID: 25830295
Characterization of BcaA, a putative classical autotransporter protein in Burkholderia pseudomallei.
Campos CG, Borst L, Cotter PA
Infect Immun 2013 Apr;81(4):1121-8
PubMed ID: 23340315