Burkholderia pseudomallei K96243, BPSS0688 (bprR)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSS0688
Name
bprR
Replicon chromosome 2
Genomic location 929989 - 930711 (- strand)

Cross-References

RefSeq YP_110702.1
GI 53721717
Entrez 3095461
GI 53721717
INSDC CAH38148.1
NCBI Locus Tag BPSS0688
RefSeq YP_110702.1,GeneID
UniParc UPI000043B9F2
UniProtKB Acc Q63MG9
UniProtKB ID Q63MG9_BURPS
UniRef100 UniRef100_Q3JG93
UniRef50 UniRef50_Q4KDD9
UniRef90 UniRef90_A3MEL5

Product

Feature Type CDS
Coding Frame 1
Product Name
two-component response regulator BprR
Product Name Confidence: Class 1
Synonyms response regulator protein
Evidence for Translation
Charge (pH 7) -3.30
Kyte-Doolittle Hydrophobicity Value -0.098
Molecular Weight (kDa) 26890.5
Isoelectric Point (pI) 5.45

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 622 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG001188 (606 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSS0688
Search term: bprR

Human Homologs

References

Perturbation of the two-component signal transduction system, BprRS, results in attenuated virulence and motility defects in Burkholderia pseudomallei.
Lazar Adler NR, Allwood EM, Deveson Lucas D, Harrison P, Watts S, Dimitropoulos A, Treerat P, Alwis P, Devenish RJ, Prescott M, Govan B, Adler B, Harper M, Boyce JD
BMC Genomics 2016 May 4;17:331
PubMed ID: 27147217