Burkholderia pseudomallei K96243, BPSS0486

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSS0486
Name
Replicon chromosome 2
Genomic location 658624 - 662499 (+ strand)

Cross-References

RefSeq YP_110508.1
GI 53721523
Entrez 3095908
GI 53721523
INSDC CAH37942.1
NCBI Locus Tag BPSS0486
RefSeq YP_110508.1,GeneID
UniParc UPI000043B932
UniProtKB Acc Q63N11
UniProtKB ID Q63N11_BURPS
UniRef100 UniRef100_Q63N11
UniRef50 UniRef50_A0A095RDG3
UniRef90 UniRef90_A0A095RDG3

Product

Feature Type CDS
Coding Frame 1
Product Name
non-ribosomal peptide synthetase
Synonyms
Evidence for Translation
Charge (pH 7) -10.47
Kyte-Doolittle Hydrophobicity Value -0.089
Molecular Weight (kDa) 138448.8
Isoelectric Point (pI) 6.30

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Extracellular Class 1
quantitative mass spectrometry evidence
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 588 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG017410 (460 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSS0486

Human Homologs

Ensembl 97, assembly GRCh38.p12
acyl-CoA synthetase family member 3 [Source:HGNC Symbol;Acc:HGNC:27288]
E-value: 2.6e-16
Percent Identity: 22.7
Ensembl 97, assembly GRCh38.p12
acyl-CoA synthetase family member 3 [Source:HGNC Symbol;Acc:HGNC:27288]
E-value: 2.6e-16
Percent Identity: 22.7
Ensembl 97, assembly GRCh38.p12
acyl-CoA synthetase family member 3 [Source:HGNC Symbol;Acc:HGNC:27288]
E-value: 2.6e-16
Percent Identity: 22.7

References

Quantitative proteomic analysis of Burkholderia pseudomallei Bsa type III secretion system effectors using hypersecreting mutants.
Vander Broek CW, Chalmers KJ, Stevens MP, Stevens JM
Mol Cell Proteomics 2015 Apr;14(4):905-16
PubMed ID: 25635268