Burkholderia pseudomallei K96243, BPSS0375 (acoE)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSS0375
Name
acoE
Replicon chromosome 2
Genomic location 514366 - 516348 (+ strand)

Cross-References

RefSeq YP_110395.1
GI 53721410
Entrez 3095797
GI 53721410
INSDC CAH37823.1
NCBI Locus Tag BPSS0375
RefSeq YP_110395.1,GeneID
UniParc UPI000043B8C4
UniProtKB Acc Q63NC4
UniProtKB ID ACSA_BURPS
UniRef100 UniRef100_A3MG40
UniRef50 UniRef50_B2JD61
UniRef90 UniRef90_A3MG40

Product

Feature Type CDS
Coding Frame 1
Product Name
acetyl-CoA synthetase
Synonyms
Evidence for Translation
Charge (pH 7) -5.57
Kyte-Doolittle Hydrophobicity Value -0.168
Molecular Weight (kDa) 72281.9
Isoelectric Point (pI) 6.36

Subcellular localization

Individual Mappings
Localization Confidence PMID
Extracellular Class 1
quantitative mass spectrometry evidence
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 585 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG002082 (667 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSS0375
Search term: acoE

Human Homologs

Ensembl 97, assembly GRCh38.p12
acyl-CoA synthetase short chain family member 2 [Source:HGNC Symbol;Acc:HGNC:15814]
E-value: 1.8e-178
Percent Identity: 48.2

References

Quantitative proteomic analysis of Burkholderia pseudomallei Bsa type III secretion system effectors using hypersecreting mutants.
Vander Broek CW, Chalmers KJ, Stevens MP, Stevens JM
Mol Cell Proteomics 2015 Apr;14(4):905-16
PubMed ID: 25635268