Burkholderia pseudomallei K96243, BPSS0244 (bhuR)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSS0244
Name
bhuR
Replicon chromosome 2
Genomic location 330905 - 333184 (- strand)

Cross-References

RefSeq YP_110263.1
GI 53721278
Entrez 3096221
GI 53721278
INSDC CAH37690.1
NCBI Locus Tag BPSS0244
RefSeq YP_110263.1,GeneID
UniParc UPI000043B842
UniProtKB Acc Q63NQ6
UniProtKB ID Q63NQ6_BURPS
UniRef100 UniRef100_Q63NQ6
UniRef50 UniRef50_A3P230
UniRef90 UniRef90_A3P230

Product

Feature Type CDS
Coding Frame 1
Product Name
BhuR
Product Name Confidence: Class 2
Synonyms exported heme receptor protein
Evidence for Translation
Detected in B. pseudomallei strain DD503 using trypsin shaving and mass spectrometry (PMID:21391724). Found in at least two preparations.
Charge (pH 7) 10.85
Kyte-Doolittle Hydrophobicity Value -0.365
Molecular Weight (kDa) 81925.3
Isoelectric Point (pI) 9.37

Subcellular localization

Individual Mappings
Localization Confidence PMID
Outer Membrane Class 3
Additional evidence for subcellular localization
Detected in Triton-insoluble fraction of lysozyme-treated B. pseudomallei DD503 cells using trypsin shaving and mass spectrometry (PMID:21391724).

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 336 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG004242 (596 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSS0244
Search term: bhuR
Search term: BhuR

Human Homologs

References

In vivo expression technology identifies a type VI secretion system locus in Burkholderia pseudomallei that is induced upon invasion of macrophages.
Shalom G, Shaw JG, Thomas MS
Microbiology 2007 Aug;153(Pt 8):2689-2699
PubMed ID: 17660433