Burkholderia pseudomallei K96243, BPSS0145 (dbpA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSS0145
Name
dbpA
Replicon chromosome 2
Genomic location 190115 - 191512 (- strand)

Cross-References

RefSeq YP_110166.1
GI 53721181
Entrez 3096710
GI 53721181
INSDC CAH37590.1
NCBI Locus Tag BPSS0145
RefSeq YP_110166.1,GeneID
UniParc UPI000043B7E1
UniProtKB Acc Q63P03
UniProtKB ID Q63P03_BURPS
UniRef100 UniRef100_Q3JHY7
UniRef50 UniRef50_P21693
UniRef90 UniRef90_A4JKT2

Product

Feature Type CDS
Coding Frame 1
Product Name
ATP-dependent RNA helicase DbpA
Synonyms
Evidence for Translation
Charge (pH 7) 2.20
Kyte-Doolittle Hydrophobicity Value -0.161
Molecular Weight (kDa) 50958.0
Isoelectric Point (pI) 7.41

Subcellular localization

Individual Mappings
Localization Confidence PMID
Extracellular Class 1
quantitative mass spectrometry evidence
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 612 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG004514 (644 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSS0145
Search term: dbpA

Human Homologs

Ensembl 97, assembly GRCh38.p12
DEAD-box helicase 6 [Source:HGNC Symbol;Acc:HGNC:2747]
E-value: 3.1e-60
Percent Identity: 34.3
Ensembl 97, assembly GRCh38.p12
DEAD-box helicase 6 [Source:HGNC Symbol;Acc:HGNC:2747]
E-value: 3.1e-60
Percent Identity: 34.3
Ensembl 97, assembly GRCh38.p12
DEAD-box helicase 6 [Source:HGNC Symbol;Acc:HGNC:2747]
E-value: 3.1e-60
Percent Identity: 34.3

References

Quantitative proteomic analysis of Burkholderia pseudomallei Bsa type III secretion system effectors using hypersecreting mutants.
Vander Broek CW, Chalmers KJ, Stevens MP, Stevens JM
Mol Cell Proteomics 2015 Apr;14(4):905-16
PubMed ID: 25635268