Burkholderia pseudomallei K96243, BPSL3362 (gcvP)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSL3362
Name
gcvP
Replicon chromosome 1
Genomic location 3986567 - 3989494 (+ strand)

Cross-References

RefSeq YP_109957.1
GI 53720971
Entrez 3092605
GI 53720971
INSDC CAH37375.1
NCBI Locus Tag BPSL3362
RefSeq YP_109957.1,GeneID
UniParc UPI000043B710
UniProtKB Acc Q63PL2
UniProtKB ID GCSP_BURPS
UniRef100 UniRef100_A3MQP3
UniRef50 UniRef50_Q54KM7
UniRef90 UniRef90_Q2STK2

Product

Feature Type CDS
Coding Frame 1
Product Name
glycine dehydrogenase
Synonyms
Evidence for Translation
Charge (pH 7) -12.58
Kyte-Doolittle Hydrophobicity Value -0.039
Molecular Weight (kDa) 104458.9
Isoelectric Point (pI) 6.37

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Extracellular Class 1
quantitative mass spectrometry evidence
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 474 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG000126 (652 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSL3362
Search term: gcvP

Human Homologs

Ensembl 97, assembly GRCh38.p12
glycine decarboxylase [Source:HGNC Symbol;Acc:HGNC:4313]
E-value: 1.3e-302
Percent Identity: 55.7

References

Quantitative proteomic analysis of Burkholderia pseudomallei Bsa type III secretion system effectors using hypersecreting mutants.
Vander Broek CW, Chalmers KJ, Stevens MP, Stevens JM
Mol Cell Proteomics 2015 Apr;14(4):905-16
PubMed ID: 25635268