Burkholderia pseudomallei K96243, BPSL3120

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSL3120
Name
Replicon chromosome 1
Genomic location 3725547 - 3726158 (- strand)

Cross-References

RefSeq YP_109713.1
GI 53720727
Entrez 3092038
GI 53720727
INSDC CAH37130.1
NCBI Locus Tag BPSL3120
RefSeq YP_109713.1,GeneID
UniParc UPI000043B627
UniProtKB Acc Q63QA5
UniProtKB ID Q63QA5_BURPS
UniRef100 UniRef100_Q2SUC1
UniRef50 UniRef50_G0AEX1
UniRef90 UniRef90_G0AEX1

Product

Feature Type CDS
Coding Frame 1
Product Name
stringent starvation protein A
Synonyms
Evidence for Translation
Charge (pH 7) -0.10
Kyte-Doolittle Hydrophobicity Value -0.209
Molecular Weight (kDa) 23680.4
Isoelectric Point (pI) 6.95

Subcellular localization

Individual Mappings
Localization Confidence PMID
Extracellular Class 1
quantitative mass spectrometry evidence
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
6V91 STRUCTURAL GENOMICS 12/12/19 Crystal structure of Stringent starvation protein A (BTH_I2974) from Burkholderia thailandensis BURKHOLDERIA THAILANDENSIS E264 1.9 X-RAY DIFFRACTION 100.0
4QQ7 TRANSFERASE 06/26/14 Crystal Structure of Putative stringent starvation protein A from Burkholderia cenocepacia with bound glutathione BURKHOLDERIA CENOCEPACIA 2.2 X-RAY DIFFRACTION 98.5

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 243 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG000352 (655 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSL3120

Human Homologs

Ensembl 97, assembly GRCh38.p12
ganglioside induced differentiation associated protein 1 like 1 [Source:HGNC Symbol;Acc:HGNC:4213]
E-value: 1.2e-05
Percent Identity: 24.9

References

Quantitative proteomic analysis of Burkholderia pseudomallei Bsa type III secretion system effectors using hypersecreting mutants.
Vander Broek CW, Chalmers KJ, Stevens MP, Stevens JM
Mol Cell Proteomics 2015 Apr;14(4):905-16
PubMed ID: 25635268