Burkholderia pseudomallei K96243, BPSL2996

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSL2996
Name
Replicon chromosome 1
Genomic location 3572554 - 3573105 (+ strand)

Cross-References

RefSeq YP_109591.1
GI 53720605
Entrez 3094711
GI 53720605
INSDC CAH37007.1
NCBI Locus Tag BPSL2996
RefSeq YP_109591.1,GeneID
UniParc UPI000043B5AF
UniProtKB Acc Q63QM7
UniProtKB ID Q63QM7_BURPS
UniRef100 UniRef100_A0A069B4G6
UniRef50 UniRef50_Q8XVL8
UniRef90 UniRef90_A0A0B6RVB8

Product

Feature Type CDS
Coding Frame 1
Product Name
hypoxanthine-guanine phosphoribosyltransferase
Synonyms
Evidence for Translation
Charge (pH 7) -3.65
Kyte-Doolittle Hydrophobicity Value -0.058
Molecular Weight (kDa) 20463.5
Isoelectric Point (pI) 5.94

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Extracellular Class 1
quantitative mass spectrometry evidence
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 449 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG000477 (654 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSL2996

Human Homologs

Ensembl 97, assembly GRCh38.p12
hypoxanthine phosphoribosyltransferase 1 [Source:HGNC Symbol;Acc:HGNC:5157]
E-value: 3.0e-11
Percent Identity: 26.5

References

Quantitative proteomic analysis of Burkholderia pseudomallei Bsa type III secretion system effectors using hypersecreting mutants.
Vander Broek CW, Chalmers KJ, Stevens MP, Stevens JM
Mol Cell Proteomics 2015 Apr;14(4):905-16
PubMed ID: 25635268