Burkholderia pseudomallei K96243, BPSL2992

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSL2992
Name
Replicon chromosome 1
Genomic location 3565723 - 3568710 (- strand)

Cross-References

RefSeq YP_109586.1
GI 53720600
Entrez 3091740
GI 53720600
INSDC CAH37002.1
NCBI Locus Tag BPSL2992
RefSeq YP_109586.1,GeneID
UniParc UPI000043B5AA
UniProtKB Acc Q63QN2
UniProtKB ID Q63QN2_BURPS
UniRef100 UniRef100_A0A069B4G2
UniRef50 UniRef50_O84834
UniRef90 UniRef90_B3CXA3

Product

Feature Type CDS
Coding Frame 1
Product Name
ribonucleotide-diphosphate reductase subunit alpha
Synonyms
Evidence for Translation
Charge (pH 7) -14.04
Kyte-Doolittle Hydrophobicity Value -0.204
Molecular Weight (kDa) 109227.7
Isoelectric Point (pI) 5.70

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Extracellular Class 1
quantitative mass spectrometry evidence
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 608 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG000482 (655 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSL2992

Human Homologs

Ensembl 97, assembly GRCh38.p12
ribonucleotide reductase catalytic subunit M1 [Source:HGNC Symbol;Acc:HGNC:10451]
E-value: 1.8e-150
Percent Identity: 41.4

References

Quantitative proteomic analysis of Burkholderia pseudomallei Bsa type III secretion system effectors using hypersecreting mutants.
Vander Broek CW, Chalmers KJ, Stevens MP, Stevens JM
Mol Cell Proteomics 2015 Apr;14(4):905-16
PubMed ID: 25635268