Burkholderia pseudomallei K96243, BPSL2984 (accC)

Gene Feature Overview

Strain	Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1 GCF_000011545.1|latest
Locus Tag	BPSL2984
Name	accC
Replicon	chromosome 1
Genomic location	3557044 - 3558411 (+ strand)

Cross-References

RefSeq	YP_109578.1
GI	53720592
Entrez	3093093
GI	53720592
INSDC	CAH36994.1
NCBI Locus Tag	BPSL2984
RefSeq	YP_109578.1,GeneID
UniParc	UPI000043B5A2
UniProtKB Acc	Q63QP0
UniProtKB ID	Q63QP0_BURPS
UniRef100	UniRef100_A0A069BBG2
UniRef50	UniRef50_P43873
UniRef90	UniRef90_Q2SZE0

Product

Feature Type	CDS
Coding Frame	1
Product Name	acetyl-CoA carboxylase biotin carboxylase subunit
Synonyms
Evidence for Translation
Charge (pH 7)	-2.55
Kyte-Doolittle Hydrophobicity Value	-0.251
Molecular Weight (kDa)	50399.3
Isoelectric Point (pI)	6.59

Subcellular localization

Individual Mappings	Localization Confidence PMID Cytoplasmic Class 3 20472543 Extracellular Class 1 quantitative mass spectrometry evidence 25635268
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 621 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group	BG000491 (654 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: BPSL2984 Search term: accC Search term: acetyl-CoA carboxylase biotin carboxylase subunit

Human Homologs

Ensembl 97, assembly GRCh38.p12	ENSP00000365456 propionyl-CoA carboxylase subunit alpha [Source:HGNC Symbol;Acc:HGNC:8653] E-value: 4.4e-120 Percent Identity: 48.1
Ensembl 97, assembly GRCh38.p12	ENSP00000365462 propionyl-CoA carboxylase subunit alpha [Source:HGNC Symbol;Acc:HGNC:8653] E-value: 4.4e-120 Percent Identity: 48.1
Ensembl 97, assembly GRCh38.p12	ENSP00000365463 propionyl-CoA carboxylase subunit alpha [Source:HGNC Symbol;Acc:HGNC:8653] E-value: 4.4e-120 Percent Identity: 48.1

References

Quantitative proteomic analysis of Burkholderia pseudomallei Bsa type III secretion system effectors using hypersecreting mutants. Vander Broek CW, Chalmers KJ, Stevens MP, Stevens JM Mol Cell Proteomics 2015 Apr;14(4):905-16 PubMed ID: 25635268