Burkholderia pseudomallei K96243, BPSL2952 (gapA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSL2952
Name
gapA
Replicon chromosome 1
Genomic location 3523351 - 3524361 (- strand)

Cross-References

RefSeq YP_109546.1
GI 53720560
Entrez 3092714
GI 53720560
INSDC CAH36962.1
NCBI Locus Tag BPSL2952
RefSeq YP_109546.1,GeneID
UniParc UPI000043B582
UniProtKB Acc Q63QS2
UniProtKB ID Q63QS2_BURPS
UniRef100 UniRef100_A0A069B4C5
UniRef50 UniRef50_Q27890
UniRef90 UniRef90_Q2SZA6

Product

Feature Type CDS
Coding Frame 1
Product Name
glyceraldehyde 3-phosphate dehydrogenase 1
Synonyms
Evidence for Translation
Detected in B. pseudomallei strain 844 using MALDI-TOF/MS analysis (37.0 kDa, pI 6.70, PMID:21960737)
Detected in B. pseudomallei strain 844 using MALDI-TOF/MS analysis (34.9 kDa, pI 4.47, PMID:21960737)
Charge (pH 7) -0.69
Kyte-Doolittle Hydrophobicity Value -0.125
Molecular Weight (kDa) 36117.7
Isoelectric Point (pI) 6.86

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Extracellular Class 1
quantitative mass spectrometry evidence
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
3GNQ OXIDOREDUCTASE 03/17/09 Crystal structure of glyceraldehyde-3-phosphate dehydrogenase, type I from Burkholderia pseudomallei BURKHOLDERIA PSEUDOMALLEI 2.4 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 607 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG000523 (655 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSL2952
Search term: gapA

Human Homologs

Ensembl 97, assembly GRCh38.p12
glyceraldehyde-3-phosphate dehydrogenase [Source:HGNC Symbol;Acc:HGNC:4141]
E-value: 4.6e-82
Percent Identity: 49.1
Ensembl 97, assembly GRCh38.p12
glyceraldehyde-3-phosphate dehydrogenase [Source:HGNC Symbol;Acc:HGNC:4141]
E-value: 4.6e-82
Percent Identity: 49.1
Ensembl 97, assembly GRCh38.p12
glyceraldehyde-3-phosphate dehydrogenase [Source:HGNC Symbol;Acc:HGNC:4141]
E-value: 4.6e-82
Percent Identity: 49.1

References

Quantitative proteomic analysis of Burkholderia pseudomallei Bsa type III secretion system effectors using hypersecreting mutants.
Vander Broek CW, Chalmers KJ, Stevens MP, Stevens JM
Mol Cell Proteomics 2015 Apr;14(4):905-16
PubMed ID: 25635268