Burkholderia pseudomallei K96243, BPSL2925

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSL2925
Name
Replicon chromosome 1
Genomic location 3492208 - 3493512 (- strand)

Cross-References

RefSeq YP_109519.1
GI 53720533
Entrez 3094709
GI 53720533
INSDC CAH36935.1
NCBI Locus Tag BPSL2925
RefSeq YP_109519.1,GeneID
UniParc UPI000043B568
UniProtKB Acc Q63QU9
UniProtKB ID Q63QU9_BURPS
UniRef100 UniRef100_A0A069B4N0
UniRef50 UniRef50_Q2SZ78
UniRef90 UniRef90_Q2SZ78

Product

Feature Type CDS
Coding Frame 1
Product Name
glutamate dehydrogenase
Synonyms
Evidence for Translation
Charge (pH 7) -2.88
Kyte-Doolittle Hydrophobicity Value -0.130
Molecular Weight (kDa) 46892.1
Isoelectric Point (pI) 6.44

Subcellular localization

Individual Mappings
Localization Confidence PMID
Extracellular Class 1
quantitative mass spectrometry evidence
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
4XGI OXIDOREDUCTASE 12/30/14 Crystal structure of Glutamate dehydrogenase from Burkholderia thailandensis BURKHOLDERIA THAILANDENSIS (STRAIN E264 / ATCC 700388 / DSM 13276 / CIP 106301) 2.0 X-RAY DIFFRACTION 97.5

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 517 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG000547 (654 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSL2925

Human Homologs

Ensembl 97, assembly GRCh38.p12
glutamate dehydrogenase 2 [Source:HGNC Symbol;Acc:HGNC:4336]
E-value: 2.5e-72
Percent Identity: 44.8

References

Quantitative proteomic analysis of Burkholderia pseudomallei Bsa type III secretion system effectors using hypersecreting mutants.
Vander Broek CW, Chalmers KJ, Stevens MP, Stevens JM
Mol Cell Proteomics 2015 Apr;14(4):905-16
PubMed ID: 25635268