Burkholderia pseudomallei K96243, BPSL2764 (tolB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSL2764
Name
tolB
Replicon chromosome 1
Genomic location 3302378 - 3303679 (+ strand)

Cross-References

RefSeq YP_109360.1
GI 53720374
Entrez 3093134
GI 53720374
INSDC CAH36772.1
NCBI Locus Tag BPSL2764
RefSeq YP_109360.1,GeneID
UniParc UPI000043B4DB
UniProtKB Acc Q63RA8
UniProtKB ID TOLB_BURPS
UniRef100 UniRef100_Q3JP75
UniRef50 UniRef50_Q1GYT1
UniRef90 UniRef90_Q2SYT0

Product

Feature Type CDS
Coding Frame 1
Product Name
translocation protein TolB
Synonyms
Evidence for Translation
Detected in B. pseudomallei strain DD503 using trypsin shaving and mass spectrometry (PMID:21391724).
Charge (pH 7) 11.68
Kyte-Doolittle Hydrophobicity Value -0.211
Molecular Weight (kDa) 45893.2
Isoelectric Point (pI) 9.91

Subcellular localization

Individual Mappings
Localization Confidence PMID
Extracellular Class 1
quantitative mass spectrometry evidence
Unknown (This protein may have multiple localization sites) Class 3
Additional evidence for subcellular localization
Detected in Triton-insoluble fraction of lysozyme-treated B. pseudomallei DD503 cells using trypsin shaving and mass spectrometry (PMID:21391724).

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 383 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG000659 (655 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSL2764
Search term: tolB

Human Homologs

References

Quantitative proteomic analysis of Burkholderia pseudomallei Bsa type III secretion system effectors using hypersecreting mutants.
Vander Broek CW, Chalmers KJ, Stevens MP, Stevens JM
Mol Cell Proteomics 2015 Apr;14(4):905-16
PubMed ID: 25635268