Burkholderia pseudomallei K96243, BPSL2628 (nusB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSL2628
Name
nusB
Replicon chromosome 1
Genomic location 3150435 - 3150872 (+ strand)

Cross-References

RefSeq YP_109224.1
GI 53720238
Entrez 3092073
GI 53720238
INSDC CAH36636.1
NCBI Locus Tag BPSL2628
RefSeq YP_109224.1,GeneID
UniParc UPI000043B464
UniProtKB Acc Q63RP4
UniProtKB ID NUSB_BURPS
UniRef100 UniRef100_A3MMR4
UniRef50 UniRef50_A3MMR4
UniRef90 UniRef90_A3MMR4

Product

Feature Type CDS
Coding Frame 1
Product Name
transcription antitermination protein NusB
Synonyms
Evidence for Translation
Charge (pH 7) 1.71
Kyte-Doolittle Hydrophobicity Value -0.270
Molecular Weight (kDa) 15981.1
Isoelectric Point (pI) 8.82

Subcellular localization

Individual Mappings
Localization Confidence PMID
Extracellular Class 1
quantitative mass spectrometry evidence
Unknown Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
6CKQ TRANSCRIPTION 02/28/18 Solution structure of the Burkholderia thailandensis transcription antitermination protein NusB (BTH_I1529) - Seattle Structural Genomics Center for Infectious Disease target ButhA.17903.a BURKHOLDERIA THAILANDENSIS (STRAIN ATCC 700388 / DSM 13276 / CIP 106301 / E264) NOT SOLUTION NMR 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 469 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG000791 (653 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSL2628
Search term: nusB

Human Homologs

References

Quantitative proteomic analysis of Burkholderia pseudomallei Bsa type III secretion system effectors using hypersecreting mutants.
Vander Broek CW, Chalmers KJ, Stevens MP, Stevens JM
Mol Cell Proteomics 2015 Apr;14(4):905-16
PubMed ID: 25635268