Burkholderia pseudomallei K96243, BPSL2289 (iscS)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSL2289
Name
iscS
Replicon chromosome 1
Genomic location 2756180 - 2757403 (- strand)

Cross-References

RefSeq YP_108885.1
GI 53719899
Entrez 3094249
GI 53719899
INSDC CAH36292.1
NCBI Locus Tag BPSL2289
RefSeq YP_108885.1,GeneID
UniParc UPI000043B314
UniProtKB Acc Q63SN1
UniProtKB ID Q63SN1_BURPS
UniRef100 UniRef100_A0A069B9I3
UniRef50 UniRef50_Q486Z0
UniRef90 UniRef90_A1V5M6

Product

Feature Type CDS
Coding Frame 1
Product Name
cysteine desulfurase
Synonyms
Evidence for Translation
Charge (pH 7) -10.22
Kyte-Doolittle Hydrophobicity Value -0.279
Molecular Weight (kDa) 45454.3
Isoelectric Point (pI) 5.85

Subcellular localization

Individual Mappings
Localization Confidence PMID
Extracellular Class 1
quantitative mass spectrometry evidence
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 652 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG002019 (654 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSL2289
Search term: iscS

Human Homologs

Ensembl 97, assembly GRCh38.p12
NFS1 cysteine desulfurase [Source:HGNC Symbol;Acc:HGNC:15910]
E-value: 3.9e-144
Percent Identity: 59.8

References

Quantitative proteomic analysis of Burkholderia pseudomallei Bsa type III secretion system effectors using hypersecreting mutants.
Vander Broek CW, Chalmers KJ, Stevens MP, Stevens JM
Mol Cell Proteomics 2015 Apr;14(4):905-16
PubMed ID: 25635268