Burkholderia pseudomallei K96243, BPSL1535 (phbA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
Locus Tag
BPSL1535
Name
phbA
Replicon chromosome 1
Genomic location 1778911 - 1780092 (+ strand)

Cross-References

RefSeq YP_108155.1
GI 53719169
Entrez 3094224
GI 53719169
INSDC CAH35536.1
NCBI Locus Tag BPSL1535
RefSeq YP_108155.1,GeneID
UniParc UPI000043B040
UniProtKB Acc Q63UR1
UniProtKB ID Q63UR1_BURPS
UniRef100 UniRef100_A0A069B8J1
UniRef50 UniRef50_Q9BWD1
UniRef90 UniRef90_A1V4H6

Product

Feature Type CDS
Coding Frame 1
Product Name
acetyl-CoA acetyltransferase
Synonyms
Evidence for Translation
Detected in B. pseudomallei strain 844 using MALDI-TOF/MS analysis (33.0 kDa, pI 6.06, PMID:21960737)
Charge (pH 7) 0.33
Kyte-Doolittle Hydrophobicity Value 0.149
Molecular Weight (kDa) 40543.4
Isoelectric Point (pI) 7.12

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Extracellular Class 1
quantitative mass spectrometry evidence
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 486 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG001627 (659 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSL1535
Search term: phbA

Human Homologs

Ensembl 86, assembly GRCh38.p7
acetyl-CoA acetyltransferase 2 [Source:HGNC Symbol;Acc:HGNC:94]
E-value: 5.6e-118
Percent Identity: 56.3

References

Quantitative Proteomic Analysis of Burkholderia pseudomallei Bsa Type III Secretion System Effectors Using Hypersecreting Mutants.
Vander Broek CW(1), Chalmers KJ(2), Stevens MP(1), Stevens JM(3).
Mol Cell Proteomics. 2015 Apr;14(4):905-16.
PubMed ID: 25635268