Burkholderia pseudomallei K96243, BPSL1535 (phbA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
Locus Tag
BPSL1535
Name
phbA
Replicon chromosome 1
Genomic location 1778911 - 1780092 (+ strand)

Cross-References

RefSeq YP_108155.1
GI 53719169
Entrez 3094224
GI 53719169
INSDC CAH35536.1
NCBI Locus Tag BPSL1535
RefSeq YP_108155.1,GeneID
UniParc UPI000043B040
UniProtKB Acc Q63UR1
UniProtKB ID Q63UR1_BURPS
UniRef100 UniRef100_A0A069B8J1
UniRef50 UniRef50_Q9BWD1
UniRef90 UniRef90_A1V4H6

Product

Feature Type CDS
Coding Frame 1
Product Name
acetyl-CoA acetyltransferase
Synonyms
Evidence for Translation
Detected in B. pseudomallei strain 844 using MALDI-TOF/MS analysis (33.0 kDa, pI 6.06, PMID:21960737)
Charge (pH 7) 0.33
Kyte-Doolittle Hydrophobicity Value 0.149
Molecular Weight (kDa) 40543.4
Isoelectric Point (pI) 7.12

Subcellular localization

Individual Mappings
Localization Confidence PMID
Extracellular Class 1
quantitative mass spectrometry evidence
Cytoplasmic Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 486 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG001627 (659 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSL1535
Search term: phbA

Human Homologs

Ensembl 86, assembly GRCh38.p7
acetyl-CoA acetyltransferase 2 [Source:HGNC Symbol;Acc:HGNC:94]
E-value: 5.6e-118
Percent Identity: 56.3

References

Quantitative Proteomic Analysis of Burkholderia pseudomallei Bsa Type III Secretion System Effectors Using Hypersecreting Mutants.
Vander Broek CW(1), Chalmers KJ(2), Stevens MP(1), Stevens JM(3).
Mol Cell Proteomics. 2015 Apr;14(4):905-16.
PubMed ID: 25635268