Burkholderia pseudomallei K96243, BPSL1478 (thrC)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSL1478
Name
thrC
Replicon chromosome 1
Genomic location 1714686 - 1716137 (+ strand)

Cross-References

RefSeq YP_108098.1
GI 53719112
Entrez 3092336
GI 53719112
INSDC CAH35479.1
NCBI Locus Tag BPSL1478
RefSeq YP_108098.1,GeneID
UniParc UPI000043B008
UniProtKB Acc Q63UW8
UniProtKB ID Q63UW8_BURPS
UniRef100 UniRef100_A0A069B1P4
UniRef50 UniRef50_P23669
UniRef90 UniRef90_Q2SWH9

Product

Feature Type CDS
Coding Frame 1
Product Name
threonine synthase
Synonyms
Evidence for Translation
Charge (pH 7) -2.95
Kyte-Doolittle Hydrophobicity Value -0.190
Molecular Weight (kDa) 53054.4
Isoelectric Point (pI) 6.58

Subcellular localization

Individual Mappings
Localization Confidence PMID
Extracellular Class 1
quantitative mass spectrometry evidence
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
3V7N LYASE 12/21/11 Crystal structure of Threonine synthase (thrC) from from Burkholderia thailandensis BURKHOLDERIA THAILANDENSIS 1.4 X-RAY DIFFRACTION 95.4

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 336 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG001687 (653 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSL1478
Search term: thrC

Human Homologs

References

Quantitative proteomic analysis of Burkholderia pseudomallei Bsa type III secretion system effectors using hypersecreting mutants.
Vander Broek CW, Chalmers KJ, Stevens MP, Stevens JM
Mol Cell Proteomics 2015 Apr;14(4):905-16
PubMed ID: 25635268