Burkholderia pseudomallei K96243, BPSL1405 (lon)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSL1405
Name
lon
Replicon chromosome 1
Genomic location 1634008 - 1636425 (+ strand)

Cross-References

RefSeq YP_108027.1
GI 53719041
Entrez 3092784
GI 53719041
INSDC CAH35406.1
NCBI Locus Tag BPSL1405
RefSeq YP_108027.1,GeneID
UniParc UPI000043AFC1
UniProtKB Acc Q63V39
UniProtKB ID Q63V39_BURPS
UniRef100 UniRef100_A0A069B8K4
UniRef50 UniRef50_P37945
UniRef90 UniRef90_B2JGL7

Product

Feature Type CDS
Coding Frame 1
Product Name
ATP-dependent protease
Synonyms
Evidence for Translation
Charge (pH 7) -4.67
Kyte-Doolittle Hydrophobicity Value -0.248
Molecular Weight (kDa) 89091.5
Isoelectric Point (pI) 6.43

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Extracellular Class 1
quantitative mass spectrometry evidence
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 569 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG001785 (653 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSL1405
Search term: lon

Human Homologs

Ensembl 97, assembly GRCh38.p12
lon peptidase 2, peroxisomal [Source:HGNC Symbol;Acc:HGNC:20598]
E-value: 1.0e-140
Percent Identity: 46.7

References

Quantitative proteomic analysis of Burkholderia pseudomallei Bsa type III secretion system effectors using hypersecreting mutants.
Vander Broek CW, Chalmers KJ, Stevens MP, Stevens JM
Mol Cell Proteomics 2015 Apr;14(4):905-16
PubMed ID: 25635268