Burkholderia cenocepacia H111, I35_RS01755 (tssA)
Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
Gene Feature Overview
| Strain |
Burkholderia cenocepacia H111
GCF_000236215.2|latest |
| Locus Tag |
I35_RS01755
|
| NCBI Old Locus Tag | I35_0339%2CI35_0378 |
| Name |
tssA
Synonym: bcsE |
| Replicon | chromosome 1 |
| Genomic location | 360756 - 361877 (+ strand) |
| Comment | Part of the T6SS gene cluster |
Cross-References
| RefSeq | WP_006494418.1 |
| GI | 493540542 |
| NCBI Locus Tag | I35_RS01755 |
| NCBI Old Locus Tag | I35_0339%2CI35_0378 |
| RefSeq | WP_006494418.1 |
Product
| Feature Type | CDS |
| Coding Frame | 1 |
| Product Name |
type VI secretion system protein TssA
|
| Synonyms |
type VI secretion protein ImpA |
| Evidence for Translation | |
| Charge (pH 7) | -25.59 |
| Kyte-Doolittle Hydrophobicity Value | -0.464 |
| Molecular Weight (kDa) | 41778.9 |
| Isoelectric Point (pI) | 4.42 |
Subcellular localization
| Individual Mappings | |
| Additional evidence for subcellular localization |
AlphaFold 2 Protein Structure Predictions
Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.
PDB 3D Structures
| Accession | Header | Accession Date | Compound | Source | Resolution | Method | Percent Identity |
| 6H8E | TRANSPORT PROTEIN | 08/02/18 | Truncated derivative of the C-terminal domain of the TssA component of the type VI secretion system from Burkholderia cenocepacia | BURKHOLDERIA CENOCEPACIA H111 | 2.35 | X-RAY DIFFRACTION | 100.0 |
| 6HS6 | TRANSPORT PROTEIN | 09/28/18 | C-terminal domain of the TssA component of the type VI secretion system from Burkholderia cenocepacia | BURKHOLDERIA CENOCEPACIA H111 | 3.08 | X-RAY DIFFRACTION | 100.0 |
| 6HS5 | TRANSPORT PROTEIN | 09/28/18 | N-terminal domain including the conserved ImpA_N region of the TssA component of the type VI secretion system from Burkholderia cenocepacia | BURKHOLDERIA CENOCEPACIA H111 | 1.8 | X-RAY DIFFRACTION | 100.0 |
| 6H8F | TRANSPORT PROTEIN | 08/02/18 | Fragment of the C-terminal domain of the TssA component of the type VI secretion system from Burkholderia cenocepacia | BURKHOLDERIA CENOCEPACIA H111 | 1.78 | X-RAY DIFFRACTION | 100.0 |
Pathogen Association Analysis
| Results | Analysis not done |
Orthologs/Comparative Genomics
| Burkholderia Ortholog Group |
BG000373 (645 members) |
| Putative Inparalogs | None Found |
Interactions
| STRING database | Search for predicted protein-protein interactions using:
Search term: I35_RS01755
Search term: tssA
Search term: type VI secretion system protein TssA
|
Human Homologs
References
|
A novel sensor kinase-response regulator hybrid controls biofilm formation and type VI secretion system activity in Burkholderia cenocepacia.
Aubert DF, Flannagan RS, Valvano MA
Infect Immun 2008 May;76(5):1979-91
PubMed ID: 18316384
|
|
Quantification of type VI secretion system activity in macrophages infected with Burkholderia cenocepacia.
Aubert DF, Hu S, Valvano MA
Microbiology 2015 Nov;161(11):2161-73
PubMed ID: 26364149
|