Burkholderia cenocepacia H111, I35_RS01725 (tssC)
Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
Gene Feature Overview
| Strain |
Burkholderia cenocepacia H111
GCF_000236215.2|latest |
| Locus Tag |
I35_RS01725
|
| NCBI Old Locus Tag | I35_0333%2CI35_0384 |
| Name |
tssC
Synonym: bcsK |
| Replicon | chromosome 1 |
| Genomic location | 352412 - 353902 (+ strand) |
| Comment | Part of the T6SS gene cluster |
Cross-References
| RefSeq | WP_006484397.1 |
| GI | 493530385 |
| NCBI Locus Tag | I35_RS01725 |
| NCBI Old Locus Tag | I35_0333%2CI35_0384 |
| RefSeq | WP_006484397.1 |
Product
| Feature Type | CDS |
| Coding Frame | 1 |
| Product Name |
type VI secretion system protein TssC
|
| Synonyms |
type VI secretion protein EvpB |
| Evidence for Translation | |
| Charge (pH 7) | -14.45 |
| Kyte-Doolittle Hydrophobicity Value | -0.278 |
| Molecular Weight (kDa) | 54822.0 |
| Isoelectric Point (pI) | 5.01 |
Subcellular localization
| Individual Mappings | |
| Additional evidence for subcellular localization |
AlphaFold 2 Protein Structure Predictions
Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.
Pathogen Association Analysis
| Results | Analysis not done |
Orthologs/Comparative Genomics
| Burkholderia Ortholog Group |
BG000367 (656 members) |
| Putative Inparalogs | None Found |
Interactions
| STRING database | Search for predicted protein-protein interactions using:
Search term: I35_RS01725
Search term: tssC
Search term: type VI secretion system protein TssC
|
Human Homologs
References
|
A novel sensor kinase-response regulator hybrid controls biofilm formation and type VI secretion system activity in Burkholderia cenocepacia.
Aubert DF, Flannagan RS, Valvano MA
Infect Immun 2008 May;76(5):1979-91
PubMed ID: 18316384
|
|
BcsKC is an essential protein for the type VI secretion system activity in Burkholderia cenocepacia that forms an outer membrane complex with BcsLB.
Aubert D, MacDonald DK, Valvano MA
J Biol Chem 2010 Nov 12;285(46):35988-98
PubMed ID: 20729192
|
|
Quantification of type VI secretion system activity in macrophages infected with Burkholderia cenocepacia.
Aubert DF, Hu S, Valvano MA
Microbiology 2015 Nov;161(11):2161-73
PubMed ID: 26364149
|