Burkholderia cenocepacia K56-2Valvano, BURCENK562V_RS04580 (lpxL)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Feature Overview

Strain Burkholderia cenocepacia K56-2Valvano
GCF_000333155.2|latest
Locus Tag
BURCENK562V_RS04580
NCBI Old Locus TagBURCENK562V_C0736
Name
lpxL
Replicon ctg7180000002936
Genomic location 606882 - 607766 (+ strand)

Cross-References

RefSeq WP_006482982.1
GI 493528965
GI 493528965
NCBI Locus Tag BURCENK562V_RS04580
NCBI Old Locus Tag BURCENK562V_C0736
RefSeq WP_006482982.1

Product

Feature Type CDS
Coding Frame 1
Product Name
lipid A biosynthesis myristoyl acyltransferase LpxL
Product Name Confidence: Class 2
Synonyms lauroyl acyltransferase
Evidence for Translation
Charge (pH 7) 11.83
Kyte-Doolittle Hydrophobicity Value -0.300
Molecular Weight (kDa) 33754.7
Isoelectric Point (pI) 9.93

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG002907 (654 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: lpxL

Human Homologs

References

The LpxL acyltransferase is required for normal growth and penta-acylation of lipid A in Burkholderia cenocepacia.
Fathy Mohamed Y, Hamad M, Ortega XP, Valvano MA
Mol Microbiol 2017 Apr;104(1):144-162
PubMed ID: 28085228