Burkholderia cenocepacia K56-2Valvano, BURCENK562V_RS05110 (paaE)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Feature Overview

Strain Burkholderia cenocepacia K56-2Valvano
Locus Tag
BURCENK562V_RS05110
NCBI Old Locus TagBURCENK562V_C6732
Name
paaE
Replicon ctg7180000002942
Genomic location 7377 - 8465 (+ strand)

Cross-References

RefSeq WP_006482925.1
GI 493528908
GI 493528908
NCBI Locus Tag BURCENK562V_RS05110
NCBI Old Locus Tag BURCENK562V_C6732
RefSeq WP_006482925.1

Product

Feature Type CDS
Coding Frame 1
Product Name
phenylacetic acid degradation protein
Product Name Confidence: Class 1
Evidence for Translation
Charge (pH 7) -12.09
Kyte-Doolittle Hydrophobicity Value -0.150
Molecular Weight (kDa) 40036.3
Isoelectric Point (pI) 4.98

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

Virulence Evidence

Source 1
Database BGD
Category Phenylacetic acid catabolism
Evidence ECO:0000315
mutant phenotype evidence used in manual assertion
Host Organism Caenorhabditis elegans
Notes paaE mutation diminishes virulence in the C. elegans model of infection
Reference 18776009

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG000236 (674 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: paaE

References

A functional phenylacetic acid catabolic pathway is required for full pathogenicity of Burkholderia cenocepacia in the Caenorhabditis elegans host model.
Law RJ(1), Hamlin JN, Sivro A, McCorrister SJ, Cardama GA, Cardona ST.
J Bacteriol. 2008 Nov;190(21):7209-18.
PubMed ID: 18776009