Burkholderia cenocepacia K56-2Valvano, BURCENK562V_RS14830 (zmpB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Feature Overview

Strain Burkholderia cenocepacia K56-2Valvano
Locus Tag
BURCENK562V_RS14830
NCBI Old Locus TagBURCENK562V_C4473
Name
zmpB
Replicon ctg7180000002940B
Genomic location 2002866 - 2004578 (+ strand)

Cross-References

RefSeq WP_006483806.1
GI 493529791
GI 493529791
NCBI Locus Tag BURCENK562V_RS14830
NCBI Old Locus Tag BURCENK562V_C4473
RefSeq WP_006483806.1

Product

Feature Type CDS
Coding Frame 1
Product Name
zinc metalloprotease ZmpB
Product Name Confidence: Class 1
Evidence for Translation
Charge (pH 7) -4.72
Kyte-Doolittle Hydrophobicity Value -0.276
Molecular Weight (kDa) 60547.5
Isoelectric Point (pI) 6.19

Subcellular localization

Individual Mappings
Localization Confidence PMID
Extracellular Class 1
Western blot evidence used in manual assertion
Extracellular Class 3
Additional evidence for subcellular localization

Virulence Evidence

Source 1
Database BGD
Category ZmpB protease
Evidence ECO:0000315
mutant phenotype evidence used in manual assertion
Host Organism Rattus norvegicus
Notes zmpB mutant is attenuated for virulence in agar bead model of chronic lung infection
Reference 16790782

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG004001 (576 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: zmpB

References

Burkholderia cenocepacia ZmpB is a broad-specificity zinc metalloprotease involved in virulence.
Kooi C, Subsin B, Chen R, Pohorelic B, Sokol PA.
Infect Immun. 2006 Jul;74(7):4083-93.
PubMed ID: 16790782