Burkholderia cenocepacia K56-2Valvano, BURCENK562V_RS12680 (cepR)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Feature Overview

Strain Burkholderia cenocepacia K56-2Valvano
Locus Tag
BURCENK562V_RS12680
NCBI Old Locus TagBURCENK562V_C4004
Name
cepR
Replicon ctg7180000002940B
Genomic location 1506805 - 1507524 (- strand)

Cross-References

RefSeq WP_020979552.1
GI 537734032
GI 537734032
NCBI Locus Tag BURCENK562V_RS12680
NCBI Old Locus Tag BURCENK562V_C4004
RefSeq WP_020979552.1

Product

Feature Type CDS
Coding Frame 1
Product Name
N-acylhomoserine lactone dependent regulatory protein CepR
Product Name Confidence: Class 1
Evidence for Translation
Charge (pH 7) -2.44
Kyte-Doolittle Hydrophobicity Value -0.059
Molecular Weight (kDa) 26625.2
Isoelectric Point (pI) 5.75

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

Virulence Evidence

Source 1
Database BGD
Category Quorum sensing system
Evidence ECO:0000315
mutant phenotype evidence used in manual assertion
Host Organism Rattus norvegicus
Notes cepR mutant attenuated for virulence in agar bead model of chronic lung infection
Reference 14663096

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG003718 (1394 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: cepR

References

The CepIR quorum-sensing system contributes to the virulence of Burkholderia cenocepacia respiratory infections.
Sokol PA(1), Sajjan U, Visser MB, Gingues S, Forstner J, Kooi C.
Microbiology. 2003 Dec;149(Pt 12):3649-58.
PubMed ID: 14663096