Burkholderia cenocepacia K56-2Valvano, BURCENK562V_RS12675 (mgtC)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Feature Overview

Strain Burkholderia cenocepacia K56-2Valvano
Locus Tag
BURCENK562V_RS12675
NCBI Old Locus TagBURCENK562V_C4003
Name
mgtC
Replicon ctg7180000002940B
Genomic location 1506054 - 1506761 (+ strand)

Cross-References

RefSeq WP_006483946.1
GI 493529931
GI 493529931
NCBI Locus Tag BURCENK562V_RS12675
NCBI Old Locus Tag BURCENK562V_C4003
RefSeq WP_006483946.1

Product

Feature Type CDS
Coding Frame 1
Product Name
MgtC
Product Name Confidence: Class 1
Evidence for Translation
Charge (pH 7) 2.59
Kyte-Doolittle Hydrophobicity Value 0.347
Molecular Weight (kDa) 24803.6
Isoelectric Point (pI) 8.33

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

Virulence Evidence

Source 1
Database BGD
Category MgtC
Evidence ECO:0000315
mutant phenotype evidence used in manual assertion
Host Organism Mus musculus
Notes mgtC mutant is defective for survival within murine RAW 264.7 macrophages
Reference 16988222

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG003717 (663 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: mgtC
Search term: MgtC

References

The mgtC gene of Burkholderia cenocepacia is required for growth under magnesium limitation conditions and intracellular survival in macrophages.
Maloney KE, Valvano MA.
Infect Immun. 2006 Oct;74(10):5477-86.
PubMed ID: 16988222