Burkholderia cenocepacia K56-2Valvano, BURCENK562V_RS29090 (wbcE)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Feature Overview

Strain Burkholderia cenocepacia K56-2Valvano
Locus Tag
BURCENK562V_RS29090
NCBI Old Locus TagBURCENK562V_C5749
Name
wbcE
Replicon ctg7180000002940C
Genomic location 105970 - 107340 (+ strand)

Cross-References

RefSeq WP_006493017.1
GI 493539127
EC Number 2.4.-.-
GI 493539127
NCBI Locus Tag BURCENK562V_RS29090
NCBI Old Locus Tag BURCENK562V_C5749
RefSeq WP_006493017.1

Product

Feature Type CDS
Coding Frame 1
Product Name
glycosyltransferase, group 1 family protein
Product Name Confidence: Class 2
Evidence for Translation
Charge (pH 7) 8.05
Kyte-Doolittle Hydrophobicity Value 0.076
Molecular Weight (kDa) 50801.4
Isoelectric Point (pI) 9.18

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

Virulence Evidence

Source 1
Database BGD
Category Lipopolysaccharide O antigen
Evidence ECO:0000315
mutant phenotype evidence used in manual assertion
Host Organism Rattus norvegicus
Notes wbcE mutant attenuated for virulence in agar bead model of chronic lung infection
Reference 15213146

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG037146 (33 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: wbcE

References

A complete lipopolysaccharide inner core oligosaccharide is required for resistance of Burkholderia cenocepacia to antimicrobial peptides and bacterial survival in vivo.
Loutet SA, Flannagan RS, Kooi C, Sokol PA, Valvano MA.
J Bacteriol. 2006 Mar;188(6):2073-80.
PubMed ID: 16513737