Burkholderia cenocepacia K56-2Valvano, BURCENK562V_RS29065 (rmlD)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Feature Overview

Strain Burkholderia cenocepacia K56-2Valvano
Locus Tag
BURCENK562V_RS29065
NCBI Old Locus TagBURCENK562V_C5744
Name
rmlD
Replicon ctg7180000002940C
Genomic location 100357 - 101265 (+ strand)

Cross-References

RefSeq WP_006485121.1
GI 493531118
EC Number 1.1.1.133
GI 493531118
NCBI Locus Tag BURCENK562V_RS29065
NCBI Old Locus Tag BURCENK562V_C5744
RefSeq WP_006485121.1

Product

Feature Type CDS
Coding Frame 1
Product Name
dTDP-4-dehydrorhamnose reductase
Product Name Confidence: Class 2
Evidence for Translation
Charge (pH 7) -4.07
Kyte-Doolittle Hydrophobicity Value -0.097
Molecular Weight (kDa) 32876.7
Isoelectric Point (pI) 5.41

Subcellular localization

Individual Mappings
Localization Confidence PMID
Periplasmic Class 3
Additional evidence for subcellular localization

Virulence Evidence

Source 1
Database BGD
Category Lipopolysaccharide O antigen
Evidence ECO:0000315
mutant phenotype evidence used in manual assertion
Host Organism Rattus norvegicus
Notes rmlD mutant attenuated for virulence in agar bead model of chronic lung infection
Reference 15213146

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG000733 (666 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: rmlD

Human Homologs

Ensembl 83, assembly GRCh38
methionine adenosyltransferase II, beta [Source:HGNC Symbol;Acc:HGNC:6905]
E-value: 3.5e-19
Percent Identity: 31.1

References

A complete lipopolysaccharide inner core oligosaccharide is required for resistance of Burkholderia cenocepacia to antimicrobial peptides and bacterial survival in vivo.
Loutet SA, Flannagan RS, Kooi C, Sokol PA, Valvano MA.
J Bacteriol. 2006 Mar;188(6):2073-80.
PubMed ID: 16513737