Burkholderia cenocepacia J2315, BCAM2237

Gene Feature Overview

Strain	Burkholderia cenocepacia J2315 GCF_000009485.1|latest
Locus Tag	BCAM2237
NCBI Locus Tag	QU43_RS65550
Name
Replicon	chromosome 2
Genomic location	2507478 - 2508779 (+ strand)

Cross-References

RefSeq	WP_006484775.1
GI	206564072
Entrez	6929814
GI	206564072
INSDC	CAR56094.1
NCBI Locus Tag	QU43_RS65550
NCBI Old Locus Tag	BCAM2237
RefSeq	WP_006484775.1,GeneID
UniParc	UPI00017BA025
UniProtKB Acc	B4EGG8
UniProtKB ID	B4EGG8_BURCJ
UniRef100	UniRef100_A0A0D1BNW0
UniRef50	UniRef50_A2QTZ7
UniRef90	UniRef90_A0A088V3D1

Product

Feature Type	CDS
Coding Frame	1
Product Name	putative 2,2-dialkylglycine decarboxylase
Synonyms
Evidence for Translation
Charge (pH 7)	-4.42
Kyte-Doolittle Hydrophobicity Value	0.085
Molecular Weight (kDa)	46452.9
Isoelectric Point (pI)	5.96

Subcellular localization

Individual Mappings	Localization Confidence PMID Cytoplasmic Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession	Header	Accession Date	Compound	Source	Resolution	Method	Percent Identity
1Z3Z	LYASE	03/14/05	The crystal structure of a DGD mutant: Q52A	BURKHOLDERIA CEPACIA	2.9	X-RAY DIFFRACTION	94.4
1M0N	LYASE	06/13/02	Structure of Dialkylglycine Decarboxylase Complexed with 1-Aminocyclopentanephosphonate	BURKHOLDERIA CEPACIA	2.2	X-RAY DIFFRACTION	94.7
1D7V	LYASE	10/19/99	CRYSTAL STRUCTURE OF THE COMPLEX OF 2,2-DIALKYLGLYCINE DECARBOXYLASE WITH NMA	BURKHOLDERIA CEPACIA	2.8	X-RAY DIFFRACTION	95.2
1M0Q	LYASE	06/13/02	Structure of Dialkylglycine Decarboxylase Complexed with S-1-aminoethanephosphonate	BURKHOLDERIA CEPACIA	2.0	X-RAY DIFFRACTION	94.7
1DKA	LYASE(DECARBOXYLASE)	06/18/93	DIALKYLGLYCINE DECARBOXYLASE STRUCTURE: BIFUNCTIONAL ACTIVE SITE AND ALKALI METAL BINDING SITES	BURKHOLDERIA CEPACIA	2.6	X-RAY DIFFRACTION	94.7
1M0O	LYASE	06/13/02	Structure of Dialkylglycine Decarboxylase Complexed with 1-Amino-1-methylpropanephosphonate	BURKHOLDERIA CEPACIA	2.4	X-RAY DIFFRACTION	94.7
1ZOD	LYASE	05/12/05	Crystal structure of dialkylglycine decarboxylase bound with cesium ion	BURKHOLDERIA CEPACIA	1.8	X-RAY DIFFRACTION	94.7
1ZOB	LYASE	05/12/05	Crystal structure of dialkylglycine decarboxylases bound with calcium ion	BURKHOLDERIA CEPACIA	2.75	X-RAY DIFFRACTION	94.7
1D7S	LYASE	10/19/99	CRYSTAL STRUCTURE OF THE COMPLEX OF 2,2-DIALKYLGLYCINE DECARBOXYLASE WITH DCS	BURKHOLDERIA CEPACIA	2.05	X-RAY DIFFRACTION	95.2
1D7U	LYASE	10/19/99	Crystal structure of the complex of 2,2-dialkylglycine decarboxylase with LCS	BURKHOLDERIA CEPACIA	1.95	X-RAY DIFFRACTION	95.2
2DKB	LYASE(DECARBOXYLASE)	07/12/94	DIALKYLGLYCINE DECARBOXYLASE STRUCTURE: BIFUNCTIONAL ACTIVE SITE AND ALKALI METAL BINDING SITES	BURKHOLDERIA CEPACIA	2.1	X-RAY DIFFRACTION	94.7
1M0P	LYASE	06/13/02	Structure of Dialkylglycine Decarboxylase Complexed with 1-Amino-1-phenylethanephosphonate	BURKHOLDERIA CEPACIA	2.6	X-RAY DIFFRACTION	94.7
1ZC9	LYASE	04/11/05	The crystal structure of dialkylglycine decarboxylase complex with pyridoxamine 5-phosphate	BURKHOLDERIA CEPACIA	2.0	X-RAY DIFFRACTION	94.7
1D7R	LYASE	10/19/99	CRYSTAL STRUCTURE OF THE COMPLEX OF 2,2-DIALKYLGLYCINE DECARBOXYLASE WITH 5PA	BURKHOLDERIA CEPACIA	2.0	X-RAY DIFFRACTION	95.2
1DGE	LYASE	06/29/94	AN ALKALI METAL ION SIZE-DEPENDENT SWITCH IN THE ACTIVE SITE STRUCTURE OF DIALKYLGLYCINE DECARBOXYLASE	BURKHOLDERIA CEPACIA	2.8	X-RAY DIFFRACTION	94.9
1DGD	LYASE	06/29/94	AN ALKALI METAL ION SIZE-DEPENDENT SWITCH IN THE ACTIVE SITE STRUCTURE OF DIALKYLGLYCINE DECARBOXYLASE	BURKHOLDERIA CEPACIA	2.8	X-RAY DIFFRACTION	94.9

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 638 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group	BG003955 (205 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: BCAM2237 Search term: putative 2,2-dialkylglycine decarboxylase

Human Homologs

Ensembl 97, assembly GRCh38.p12

ENSP00000231420 alanine--glyoxylate aminotransferase 2 [Source:HGNC Symbol;Acc:HGNC:14412] E-value: 4.7e-47 Percent Identity: 27.6

References