Burkholderia cenocepacia J2315, BCAL2872 (rpoE1)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia cenocepacia J2315
GCF_000009485.1|latest
Locus Tag
BCAL2872
NCBI Locus TagQU43_RS50995
Name
rpoE1
Synonym: ecfA2
Replicon chromosome 1
Genomic location 3153078 - 3153677 (- strand)

Cross-References

RefSeq WP_006490873.1
GI 206561207
Entrez 6934123
GI 206561207
NCBI Locus Tag QU43_RS50995
NCBI Old Locus Tag BCAL2872
RefSeq WP_006490873.1,GeneID
UniProtKB Acc B4EAI0
UniProtKB ID B4EAI0_BURCJ

Product

Feature Type CDS
Coding Frame 1
Product Name
RNA polymerase sigma factor RpoE
Product Name Confidence: Class 1
Synonyms EcfA2
Evidence for Translation
Charge (pH 7) -2.79
Kyte-Doolittle Hydrophobicity Value -0.372
Molecular Weight (kDa) 22593.5
Isoelectric Point (pI) 5.21

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 496 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG000968 (655 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BCAL2872
Search term: rpoE1

Human Homologs

References

Architecture of Burkholderia cepacia complex sigma70 gene family: evidence of alternative primary and clade-specific factors, and genomic instability.
Menard A, de Los Santos PE, Graindorge A, Cournoyer B
BMC Genomics 2007 Sep 4;8:308
PubMed ID: 17784948
Burkholderia cenocepacia requires RpoE for growth under stress conditions and delay of phagolysosomal fusion in macrophages.
Flannagan RS, Valvano MA
Microbiology 2008 Feb;154(Pt 2):643-653
PubMed ID: 18227267