Burkholderia cenocepacia J2315, BCAL2831

Gene Feature Overview

Strain	Burkholderia cenocepacia J2315 GCF_000009485.1|latest
Locus Tag	BCAL2831
NCBI Locus Tag	QU43_RS50770
Name
Replicon	chromosome 1
Genomic location	3109477 - 3110139 (- strand)

Cross-References

RefSeq	WP_006481728.1
GI	206561168
Entrez	6932828
GI	206561168
INSDC	CAR53131.1
NCBI Locus Tag	QU43_RS50770
NCBI Old Locus Tag	BCAL2831
RefSeq	WP_006481728.1,GeneID
UniParc	UPI0000E5DA81
UniProtKB Acc	B4EA15
UniProtKB ID	B4EA15_BURCJ
UniRef100	UniRef100_B1JXY3
UniRef50	UniRef50_C9Y701
UniRef90	UniRef90_Q39DC3

Product

Feature Type	CDS
Coding Frame	1
Product Name	two-component regulatory system, response regulator protein Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Charge (pH 7)	-2.28
Kyte-Doolittle Hydrophobicity Value	0.002
Molecular Weight (kDa)	23939.3
Isoelectric Point (pI)	5.80

Subcellular localization

Individual Mappings	Localization Confidence PMID Cytoplasmic Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 621 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group	BG002477 (1281 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: BCAL2831 Search term: two-component regulatory system, response regulator protein

Human Homologs

References

A two-tier model of polymyxin B resistance in Burkholderia cenocepacia. Loutet SA, Mussen LE, Flannagan RS, Valvano MA Environ Microbiol Rep 2011 Apr;3(2):278-85 PubMed ID: 23761261

Burkholderia cenocepacia requires a periplasmic HtrA protease for growth under thermal and osmotic stress and for survival in vivo. Flannagan RS, Aubert D, Kooi C, Sokol PA, Valvano MA Infect Immun 2007 Apr;75(4):1679-89 PubMed ID: 17220310