Burkholderia cenocepacia J2315, BCAL1675 (amrB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia cenocepacia J2315
Locus Tag
BCAL1675
NCBI Locus TagQU43_RS44900
Name
amrB
Replicon chromosome 1
Genomic location 1830038 - 1833178 (+ strand)

Cross-References

RefSeq WP_006487247.1
GI 206560037
Entrez 6933295
GI 206560037
INSDC CAR51973.1
NCBI Locus Tag QU43_RS44900
NCBI Old Locus Tag BCAL1675
RefSeq WP_006487247.1,GeneID
UniParc UPI00017B9281
UniProtKB Acc B4E8U7
UniProtKB ID B4E8U7_BURCJ
UniRef100 UniRef100_B4E8U7
UniRef50 UniRef50_P31224
UniRef90 UniRef90_A9AIV5

Product

Feature Type CDS
Coding Frame 1
Product Name
multidrug efflux protein
Synonyms
Evidence for Translation
Charge (pH 7) 7.17
Kyte-Doolittle Hydrophobicity Value 0.352
Molecular Weight (kDa) 111695.7
Isoelectric Point (pI) 9.14

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AMR gene predictions from CARD database

Identified using the Resistance Gene Identifier (RGI)

Model Name Definition Accession Model Type (?) SNP Cutoff E-value Percent Identity CARD Version
amrB amrB is the membrane fusion protein of the AmrAB-OprM multidrug efflux complex. ARO:3002983 protein homolog model Strict 0.0 86.6 1.2.1

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 487 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG001444 (2569 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BCAL1675
Search term: amrB

References

Assessment of three Resistance-Nodulation-Cell Division drug efflux transporters of Burkholderia cenocepacia in intrinsic antibiotic resistance.
Buroni S, Pasca MR, Flannagan RS, Bazzini S, Milano A, Bertani I, Venturi V, Valvano MA, Riccardi G.
BMC Microbiol. 2009 Sep 17;9:200.
PubMed ID: 19761586