Burkholderia cenocepacia J2315, BCAL0352

Gene Feature Overview

Strain	Burkholderia cenocepacia J2315 GCF_000009485.1|latest
Locus Tag	BCAL0352
NCBI Locus Tag	QU43_RS38295
Name	Synonym: bcsA
Replicon	chromosome 1
Genomic location	383182 - 384027 (- strand)
Comment	Part of the T6SS gene cluster

Cross-References

RefSeq	WP_006488977.1
GI	206558758
Entrez	6930896
GI	206558758
INSDC	CAR50662.1
NCBI Locus Tag	QU43_RS38295
NCBI Old Locus Tag	BCAL0352
RefSeq	WP_006488977.1,GeneID
UniParc	UPI00017B9130
UniProtKB Acc	B4E6S4
UniProtKB ID	B4E6S4_BURCJ
UniRef100	UniRef100_B4E6S4
UniRef50	UniRef50_C5AA76
UniRef90	UniRef90_A9AJ86

Product

Feature Type	CDS
Coding Frame	1
Product Name	subfamily M15C metalopeptidase Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Charge (pH 7)	10.44
Kyte-Doolittle Hydrophobicity Value	-0.109
Molecular Weight (kDa)	31344.0
Isoelectric Point (pI)	10.29

Subcellular localization

Individual Mappings	Localization Confidence PMID Unknown Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 27 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group	BG000379 (642 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: BCAL0352 Search term: subfamily M15C metalopeptidase

Human Homologs

References

A novel sensor kinase-response regulator hybrid controls biofilm formation and type VI secretion system activity in Burkholderia cenocepacia. Aubert DF, Flannagan RS, Valvano MA Infect Immun 2008 May;76(5):1979-91 PubMed ID: 18316384

Anchoring the type VI secretion system to the peptidoglycan: TssL, TagL, TagP... what else? Aschtgen MS, Thomas MS, Cascales E Virulence 2010 Nov-Dec;1(6):535-40 PubMed ID: 21178498

Quantification of type VI secretion system activity in macrophages infected with Burkholderia cenocepacia. Aubert DF, Hu S, Valvano MA Microbiology 2015 Nov;161(11):2161-73 PubMed ID: 26364149