Burkholderia cenocepacia J2315, BCAL0145 (ahcY)

Gene Feature Overview

Strain	Burkholderia cenocepacia J2315 GCF_000009485.1|latest
Locus Tag	BCAL0145
NCBI Locus Tag	QU43_RS37230
Name	ahcY
Replicon	chromosome 1
Genomic location	169124 - 170542 (+ strand)

Cross-References

RefSeq	WP_006484031.1
GI	206558550
Entrez	6933582
GI	206558550
INSDC	CAR50453.1
NCBI Locus Tag	QU43_RS37230
NCBI Old Locus Tag	BCAL0145
RefSeq	WP_006484031.1,GeneID
UniParc	UPI00017B8F23
UniProtKB Acc	B4EE70
UniProtKB ID	B4EE70_BURCJ
UniRef100	UniRef100_B4EE70
UniRef50	UniRef50_P50250
UniRef90	UniRef90_Q2STU0

Product

Feature Type	CDS
Coding Frame	1
Product Name	S-adenosyl-L-homocysteine hydrolase
Synonyms
Evidence for Translation
Charge (pH 7)	-7.32
Kyte-Doolittle Hydrophobicity Value	-0.176
Molecular Weight (kDa)	52167.0
Isoelectric Point (pI)	6.20

Subcellular localization

Individual Mappings	Localization Confidence PMID Cytoplasmic Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession	Header	Accession Date	Compound	Source	Resolution	Method	Percent Identity
3D64	HYDROLASE	05/18/08	Crystal structure of S-adenosyl-L-homocysteine hydrolase from Burkholderia pseudomallei	BURKHOLDERIA PSEUDOMALLEI	2.3	X-RAY DIFFRACTION	94.7
3GLQ	HYDROLASE	03/12/09	Crystal structure of S-adenosyl-L-homocysteine hydrolase from Burkholderia pseudomallei in complex with 9-beta-D-arabino-furansyl-adenine	BURKHOLDERIA PSEUDOMALLEI 1710B	2.3	X-RAY DIFFRACTION	94.7

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 500 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group	BG000178 (654 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: BCAL0145 Search term: ahcY Search term: S-adenosyl-L-homocysteine hydrolase

Human Homologs

Ensembl 97, assembly GRCh38.p12

ENSP00000217426 adenosylhomocysteinase [Source:HGNC Symbol;Acc:HGNC:343] E-value: 3.0e-148 Percent Identity: 59.3

References