Burkholderia mallei ATCC 23344, BMAA1542 (bsaQ)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Burkholderia mallei ATCC 23344
GCF_000011705.1|latest
Locus Tag
BMAA1542
Name
bsaQ
Synonym: sctV
Replicon chromosome 2
Genomic location 1669851 - 1671923 (- strand)
CommentThis gene is part of the Burkholderia mallei type III secretion system T3SS-3 gene locus.

Cross-References

RefSeq YP_106131.1
GI 53716327
NCBI Locus Tag BMAA1542
RefSeq YP_106131.1,GeneID

Product

Feature Type CDS
Coding Frame 1
Product Name
type III secretion system export apparatus protein BsaQ (T3SS-3)
Product Name Confidence: Class 2
Synonyms type III secretion system protein BsaQ
Evidence for Translation
Charge (pH 7) -3.82
Kyte-Doolittle Hydrophobicity Value 0.552
Molecular Weight (kDa) 74415.8
Isoelectric Point (pI) 5.87

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Virulence Evidence

Source 1
Database BGD
Category T3SS-3
Evidence ECO:0000315
mutant phenotype evidence used in manual assertion
Host Organism Mus musculus
Notes
Reference 14742564
Source 2
Database VFDB : VF0428
Category T3SS-3
Evidence ECO:0000250
sequence similarity evidence used in manual assertion
Host Organism
Notes
Annotation transferred from Burkholderia pseudomallei K96243
Reference 17984080
Source 3
Database BGD
Category T3SS-3
Evidence ECO:0000315
mutant phenotype evidence used in manual assertion
Host Organism Mesocricetus auratus
Notes
Reference 14742564

Pathogen Association Analysis

Results Analysis not done

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG019847 (326 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BMAA1542
Search term: bsaQ

Human Homologs

References

Type III Secretion in the Melioidosis Pathogen <i>Burkholderia pseudomallei</i>.
Vander Broek CW, Stevens JM
Front Cell Infect Microbiol 2017;7:255
PubMed ID: 28664152
Inactivation of Burkholderia pseudomallei bsaQ results in decreased invasion efficiency and delayed escape of bacteria from endocytic vesicles.
Muangsombut V, Suparak S, Pumirat P, Damnin S, Vattanaviboon P, Thongboonkerd V, Korbsrisate S
Arch Microbiol 2008 Dec;190(6):623-31
PubMed ID: 18654761
Caspase-1 dependent macrophage death induced by Burkholderia pseudomallei.
Sun GW, Lu J, Pervaiz S, Cao WP, Gan YH
Cell Microbiol 2005 Oct;7(10):1447-58
PubMed ID: 16153244